Friday night sees Essendon and Collingwood clash at the MCG to get us underway.
Brisbane v St Kilda presents as the feature fixture of the five on Saturday, before Carlton and GWS meet on Sunday evening in what could be a very vital match.
Who wins this weekend?
Check out the tips from our SEN experts:
Dwayne Russell
Running tally: 142
Collingwood
Hawthorn
Gold Coast
Brisbane
Western Bulldogs
Adelaide
Port Adelaide
Melbourne
Carlton
Garry Lyon
Running tally: 136
Collingwood
Hawthorn
Gold Coast
Brisbane
Western Bulldogs
Adelaide
Port Adelaide
Melbourne
Carlton
Gerard Whateley
Running tally: 131
Collingwood
Hawthorn
Gold Coast
Brisbane
Geelong
Adelaide
Port Adelaide
Melbourne
Carlton
Andy Maher
Running tally: 130
Collingwood
Hawthorn
Gold Coast
Brisbane
Western Bulldogs
Adelaide
Port Adelaide
Melbourne
Carlton
Sam Edmund
Running tally: 129
Collingwood
Hawthorn
Gold Coast
Brisbane
Western Bulldogs
Adelaide
Port Adelaide
Sydney
Carlton
Tim Watson
Running tally: 128
Collingwood
Hawthorn
Gold Coast
Brisbane
Western Bulldogs
Adelaide
Port Adelaide
Melbourne
Carlton
Gareth Hall
Running tally: 127
Essendon
Hawthorn
North Melbourne
Brisbane
Western Bulldogs
West Coast
Port Adelaide
Melbourne
GWS
Campbell Brown
Running tally: 122
Collingwood
Hawthorn
Gold Coast
Brisbane
Western Bulldogs
Adelaide
Port Adelaide
Sydney
Carlton
Andrew Gaze
Running tally: 119
Essendon
Hawthorn
North Melbourne
St Kilda
Geelong
West Coast
Richmond
Sydney
GWS