The weekend's action kicks off on Thursday night with the Broncos v Roosters at the Gabba.
The Storm v Eels headlines two Friday fixtures, before a trio of Saturday matches highlighted by Panthers v Sharks.
The Titans v Cowboys on the Gold Coast is one of two Sunday matches.
Who are we tipping in Round 22?
Check out the tips from our SEN League experts:
Pat Welsh
Running tally: 103
Broncos
Rabbitohs
Storm
Raiders
Sea Eagles
Panthers
Bulldogs
Cowboys
Greg Alexander
Running tally: 101
Broncos
Rabbitohs
Storm
Newcastle
Sea Eagles
Panthers
Dolphins
Cowboys
Bryan Fletcher
Running tally: 100
Broncos
Rabbitohs
Storm
Raiders
Sea Eagles
Panthers
Bulldogs
Cowboys
Scott Sattler
Running tally: 96
Broncos
Rabbitohs
Storm
Raiders
Sea Eagles
Panthers
Dolphins
Cowboys
Jimmy Smith
Running tally: 96
Broncos
Rabbitohs
Storm
Raiders
Sea Eagles
Panthers
Bulldogs
Cowboys
Joel Caine
Running tally: 95
Broncos
Rabbitohs
Storm
Raiders
Sea Eagles
Panthers
Dolphins
Cowboys
Andrew Voss
Running tally: 93
Broncos
Rabbitohs
Eels
Raiders
Sea Eagles
Panthers
Dolphins
Cowboys
Matt White
Running tally: 93
Broncos
Rabbitohs
Storm
Raiders
Sea Eagles
Panthers
Dolphins
Cowboys
Mat Rogers
Running tally: 90
Broncos
Rabbitohs
Storm
Knights
Sea Eagles
Panthers
Dolphins
Cowboys
The tips are in! Play SEN’s NRL Tipping and you can take them on by joining the Tool Kit Depot league (league code N46I3EFK).
There’s $14K+ worth of prizes up for grabs, plus prizes for weekly winners! PLAY NOW at nrltipping.sen.com.au