The teams have been named for Round 2 and there are some surprising omissions to say the least!
Check out each game's notable changes below.
Sydney v Geelong
Friday - 7.50pm - SCG
Geelong has regained star midfielder Mitch Duncan and reliable defender Jed Bews for their Friday night game against Sydney, while Jeremy Cameron has also been named after being subbed out last week with a hip pointer injury.
Youngster Sam De Koning misses after suffering concussion.
For the Swans, Jake Lloyd and Chad Warner return after coming out of health and safety protocols, however they lose running defender Justin McInerney to injury.
Collingwood v Adelaide
Saturday - 1.45pm - MCG
Collingwood forward Mason Cox will miss after copping numerous injuries during last week’s win over the Saints, while Nathan Kreuger will make his club debut after missing Round 1 with suspension.
Will Hoskin-Elliot returns for the Pies as well, but the big news is at Adelaide.
Top five draft pick Riley Thilthorpe has been dropped after kicking a goal last week, while Wayne Milera has suffered the same fate after his return from a lengthy injury layoff.
Essendon v Brisbane
Saturday - 4.35pm - Marvel
Essendon has welcomed back Jake Stringer to their side for the important clash with the Lions this week. He comes back into the side after recovering from a groin niggle, while Kyle Langford misses with what could be a 10-week hamstring injury.
Rising Star Nick Martin is in health and safety protocols, however Aaron Francis has overcome a knee injury to be selected.
Mitch Robinson will miss for the Lions after failing to overturn his suspension at the Tribunal.
Port Adelaide v Hawthorn
Saturday - 7.40 - Adelaide Oval
Port Adelaide has called in just two names after their injury crisis last week, including Josh Sinn as a potential debutant. Sam Skinner is also on the list of ins, while Aliir Aliir, Robbie Gray (both injured) and Jackson Mead (omitted) all go out.
Meanwhile, Hawks captain Ben McEvoy returns alongside Luke Breust, the duo COVID-forced absentees last week. However, Sam Mitchell has made the curious decision to omit veteran midfielder Liam Shiels.
Gold Coast v Melbourne
Saturday - 8pm - Metricon Stadium
Christian Salem has been ruled out for up to two months after undergoing knee surgery, and he is replaced by Trent Rivers as the Demons look to go 2-0, while the Suns are unchanged.
North Melbourne v West Coast
Sunday - 1.10pm - Marvel
North Melbourne has reacted savagely to Jaidyn Stephenson’s poor game last week, dropping their prized recruit. Stephenson had 11 touches and five clangers last week, with David Noble not accepting the sub-par performance. Jarred Polec, comes back in, while Josh Walker also slots into the back half.
While West Coast Eagles have lost Josh Kennedy for Sunday’s important clash against North Melbourne, the reinforcements have been called in. Jack Darling, Luke Shuey, Tim Kelly, Alex Witherden and Liam Ryan have all been named in a huge boost as the Eagles look to avoid starting the year 0-2.
Tom Barrass and Jack Redden accompany Kennedy as notable outs, all three due to health and safety protocols.
Richmond v Greater Western sydney
Sunday - 3.20pm - MCG
Richmond has named Dustin Martin despite the Brownlow Medallist taking a few days' leave, however he is still no lock for the game. Jack Riewoldt and Dion Prestia have been left out of the Tigers’ 22 after suffering injuries against Carlton last week.
The Giants have recalled Jesse Hogan and Nick Haynes as they look to cause an upset.
Fremantle v St Kilda
Sunday - 6.20 - Optus Stadium
Fremantle has recalled Sean Darcy after the ruckman overcame calf soreness, however his skipper, Nat Fyfe, will miss with a back injury. Fyfe missed last week with a knee injury and missed the majority of the pre-season due to complications from shoulder surgery, with the latest setback another big blow. David Mundy and Brennan Cox also go out due to health and safety protocols.
St Kilda has confirmed first-round draft pick Nasiah Wanganeen-Milera will make his debut after being the unused medical sub last week, while Paddy Ryder makes his return to the big time through the VFL this weekend.