Brisbane has had an unlucky week with injury, with second-year midfielder Connor McFadyen tearing his ACL.
McFadyen suffered the injury during a Lions match practice.
The 19-year-old was selected as an academy pick back in 2018.
On a positive note, captain Dayne Zorko is expected to return this weekend from a calf injury.
Defender Marcus Adams will miss two months after re-injuring the foot he had an operation on following Round 1.
Adams has struggled with a number of injuries across his career and the Lions are reporting that he now has a stress fracture in the foot.
Cam Ellis-Yolmen suffered a calf injury early on in the side’s win over Port Adelaide as well.
He is expected to miss one to two weeks.